Organic & biomolecular chemistry

Synthesis and biological evaluation of caulibugulones A–E

P Wipf, B Joo, T Nguyen, JS Lazo

文献索引：Wipf, Peter; Joo, Beomjun; Nguyen, Theresa; Lazo, John S. Organic and Biomolecular Chemistry, 2004 , vol. 2, # 15 p. 2173 - 2174

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被引用次数: 35

摘要

Recently, the Gustafson group at the National Cancer Institute (NCI) reported the isolation of caulibugulones A–F, a series of novel cytotoxic isoquinoline quinones and iminoquinones, from an extract of the marine bryozoan Caulibugula intermis (Fig. 1). 1 They also disclosed that caulibugulones A–F exhibited IC 50 's of 0.03–1.67 µg mL −1 against murine tumor cells based on an in vitro cytotoxicity assay. These compounds attracted our attention because of our prior ...