Tetrahedron letters

Total synthesis of the marine cytotoxic caulibugulones A–D

D Alagille, RM Baldwin, GD Tamagnan

文献索引：Alagille, David; Baldwin, Ronald M.; Tamagnan, Gilles D. Tetrahedron Letters, 2004 , vol. 45, # 32 p. 6179 - 6181

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被引用次数: 15

摘要

Marine organisms such as sponges, tunicates, coelenterates, and phytoplankton have proven to be a valuable source of biologically active secondary metabolites. 1 Very recently, Milanowski et al. 2 identified four new isoquinoline quinone derivatives and two iminoquinones, termed caulibugulones A–F (Fig. 1) from the marine bryozoan Caulibugula intermis Harmer (Bugulidae) and reported interesting cytotoxic activity. A number of isoquinoline quinones, including the renierones ...