Life sciences

Identification and synthesis of novel alkaloids from the root system of Nicotiana tabacum: affinity for neuronal nicotinic acetylcholine receptors

X Wei, SP Sumithran, AG Deaciuc, HR Burton, LP Bush…

文献索引：Wei, Xiaochen; Sumithran, Sangeetha P.; Deaciuc, A. Gabriela; Burton, Harold R.; Bush, Lowell P.; Dwoskin, Linda P.; Crooks, Peter A. Life Sciences, 2005 , vol. 78, # 5 p. 495 - 505

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被引用次数: 49

摘要

A novel pyridine derivative, 3, 5-bis-(1-methyl-pyrrolidin-2-yl)-pyridine, and a pair of diastereomers of 1, 1′-dimethyl-[2, 3′] bipyrrolidinyl were isolated from the root of Nicotiana tabacum plants and identified as novel alkaloids by GC-MS analysis. The structures of these new alkaloids were confirmed by total synthesis. The affinities of these novel alkaloids, and other structurally related compounds for α4β2*, α7* neuronal nicotinic ...