Synthesis of 2-bromo-7-methyl-3, 5-dihydro-imidazo [4, 5-d] pyridazin-4-one and 3-alkyl-2-bromo-3, 5-dihydro-imidazo [4, 5-d] pyridazin-4-one and their selective …
M Eckhardt, N Hauel, E Langkopf, F Himmelsbach
文献索引：Eckhardt, Matthias; Hauel, Norbert; Langkopf, Elke; Himmelsbach, Frank Tetrahedron Letters, 2008 , vol. 49, # 12 p. 1931 - 1934
Two synthetic routes to the versatile 3, 5-dihydro-imidazo [4, 5-d] pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished.
