Synthesis

One-step coupling of tris (hydroxymethyl) aminomethane to aliphatic and aromatic carboxylic acids

I Villanueva, B Hernandez, V Chang, MD Heagy

文献索引：Villanueva; Hernandez; Chang; Heagy Synthesis, 2000 , # 10 p. 1435 - 1438

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被引用次数: 5

摘要

Abstract: A convenient and general method was established to append tri-, hexa-, and nonadentate ligands about an aromatic or aliphatic core. This approach allows a variety of commercially available carboxylic acids to be transformed to their N-tris (hydroxymethyl) methylcarboxamides in one step. The selective activation of the acid functionality to form the polyhydroxylated dendritic cores has been achieved using the acyl transfer agent N- ...