Safe and efficient in vitro and in vivo gene delivery: tripodal cationic lipids with programmed biodegradability

A Unciti-Broceta, L Moggio, K Dhaliwal…

文献索引：Unciti-Broceta, Asier; Moggio, Loredana; Dhaliwal, Kevin; Pidgeon, Laura; Finlayson, Keith; Haslett, Chris; Bradley, Mark Journal of Materials Chemistry, 2011 , vol. 21, # 7 p. 2154 - 2158

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被引用次数: 7

摘要

The therapeutic use of nucleic acids has long been heralded as a panacea of medicinal opportunity, a vision enhanced by the introduction of RNA interference technology. The Achilles heel of such an approach is the in vivo delivery of the desired nucleic acid into cells, a practice that lacks selectivity, safety and/or efficiency. Herein we report the safe and efficacious in vitro and in vivo delivery of nucleic acids using tripodal biodegradable ...