Use of a temporary “solubilizing” peptide tag for the Fmoc solid-phase synthesis of human insulin glargine via use of regioselective disulfide bond formation

MA Hossain, A Belgi, F Lin, S Zhang…

文献索引：Englebretsen, Darren R.; Robillard, George T. Tetrahedron, 1999 , vol. 55, # 21 p. 6623 - 6634

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被引用次数: 43

摘要

... Volume: Page ... Consequently, one of the first attempts to exploit this to address the problem of poor synthetic peptide solubility was undertaken by Englebretsen and his colleagues who used Boc-SPPS to attach a solubilizing poly-(Gly-Arg)-Gly peptide via a base ...