European journal of medicinal chemistry

Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-Aryl-substituted 2-bis-1H-benzimidazoles

M Singh, V Tandon

文献索引：Singh, Manish; Tandon, Vibha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669

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被引用次数: 50

摘要

Inhibitors of topoisomerase I constitute a novel family of antitumor agents. The class of benzimidazole derivatives contains compounds possessing affinity to DNA. For example, fluorescent stains Hoechst 33342 and Hoechst 33258 interact with DNA as ligand and produce nonspecific inhibition of the catalytic activity of many enzymes involved in DNA synthesis, including DNA topoisomerase and DNA helicase. Several 2-aryl-5-substituted- ...