Novel protein kinase C inhibitors: α-terthiophene derivatives

…, CL Ashendel, Q Zhou, ES Lee, C Chang

文献索引：Kim, Darrick S. H. L.; Ashendel, Curtis L.; Zhou, Qin; Chang, Ching-Te; Lee, Eung-Seok; Chang, Ching-Jer Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2695 - 2698

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被引用次数: 49

摘要

A series of α-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC50< 1 μM). α-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.