Carbonic anhydrase inhibitors. Part 37. Novel classes of isozyme I and II inhibitors and their mechanism of action. Kinetic and spectroscopic investigations on native …
…, R Pierattelli, A Scozzafava, CT Supuran
文献索引：Briganti; Pierattelli; Scozzafava; Supuran European Journal of Medicinal Chemistry, 1996 , vol. 31, # 12 p. 1001 - 1010
The interaction of Zn (II)-and Co (II)-carbonic anhydrase (CA) with a series of compounds possessing moieties resembling the aromatic sulfonamides, such as sulfamide, sulfamic acid, N-substituted aromatic sulfonamides, sulfenamides, sulfinic and seleninic acids, was investigated using kinetic and spectroscopic techniques. All these compounds inhibit the hydrasic and esterasic activity of the enzyme. Their binding within the active site of ...
