Identification of novel chromenone derivatives as interleukin-5 inhibitors

E Venkateswararao, MS Kim, VK Sharma…

文献索引：Venkateswararao, Eeda; Kim, Min-Seok; Sharma, Vinay K.; Lee, Ki-Cheul; Subramanian, Santhosh; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 31 - 38

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被引用次数: 7

摘要

A series of (E)-5-alkoxy-3-(3-phenyl-3-oxoprop-1-enyl)-4H-chromen-4-ones (4) and (E)-5- alkoxy-3-(3-hydroxy-3-phenylprop-1-enyl)-4H-chromen-4-ones (5) were synthesized and evaluated for their IL-5 inhibitory activity. Propenone analogs 4 possess some of the structurally important characteristics of isoflavone 2 and chalcone 3 previously known as potent IL-5 inhibitor. However, the inhibitory activity of 4 was weak and therefore this ...