Some Cardiovascular Effects of a Series of Aryloxyalkylamines. II1

J Augstein, WC Austin, CA Bartram…

文献索引：Augstein,J. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 812 - 818

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被引用次数: 4

摘要

Compounds IV and T', in the fashion of a typical adrenolytic, both reverse the pressor effects of epinephrine while abolishing those due to norepinephrine. Compound IT.-like 111, was not active after oral administration, although highly active by the intravenouq route. Compound IT, in dogs, appears, however, to act inairily by a central effect. At an oral dose of 2.5 nig,'l; g in dogs a sustained antihypertensive response was elicited which lasted more ...