Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents

…, J Dong, D Chen, J Liu, L Zhang, X Wen

文献索引：Zhang, Liying; Jia, Xiaojian; Dong, Jizhe; Chen, Dongyin; Liu, Jun; Zhang, Luyong; Wen, Xiaoan Chemical Biology and Drug Design, 2014 , vol. 83, # 3 p. 297 - 305

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被引用次数: 8

摘要

Antidiabetic agents simultaneously inhibiting hepatic glucose production and stimulating hepatic glucose consumption could apply a better control over hyperglycemia. A series of oleanolic acid derivatives with bulky substituents at C-3 position were designed and synthesized in order to search for this kind of agents. All of the compounds were evaluated biologically in vitro using glycogen phosphorylase and HepG2 cells. The results indicated ...