Archiv der Pharmazie

Resveratrol derived butyrylcholinesterase inhibitors

R Csuk, S Albert, R Kluge, D Ströhl

文献索引：Csuk, Rene; Albert, Sabrina; Kluge, Ralph; Stroehl, Dieter Archiv der Pharmazie, 2013 , vol. 346, # 7 p. 499 - 503

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被引用次数: 10

摘要

Novel polyhydroxylated (E)-stilbenes were synthesized by Mizoroki–Heck reactions and tested for their ability to inhibit the enzymes acetyl-and butyrylcholinesterase. Several of them are good inhibitors of butyrylcholinesterase; one of them carrying an extra fluorine substituent is a 94-fold stronger inhibitor of butyrylcholinesterase than of acetylcholinesterase. Keywords: Acetylcholinesterase/Alzheimer disease/ ...