Tetrahedron

One-pot two-step synthesis of 4-vinylphenols from 4-hydroxy substituted benzaldehydes under microwave irradiation: a new perspective on the classical Knoevenagel …

AK Sinha, A Sharma, BP Joshi

文献索引：Sinha, Arun K.; Sharma, Anuj; Joshi, Bhupendra P. Tetrahedron, 2007 , vol. 63, # 4 p. 960 - 965

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被引用次数: 69

摘要

The classical Knoevenagel–Doebner reaction is reinvestigated wherein the direct synthesis of substituted 4-vinylphenols instead of the expected 4-hydroxycinnamic acids is described. The condensation reaction is performed on 4-hydroxy substituted benzaldehydes and malonic acid with a mixture of acetic acid–piperidine as condensing agent under focused microwave irradiation. The occurrence of simultaneous condensation–double ...