The synthesis of radiolabeled Irbesartan using N, N??dimethyl [14C] formamide as a source of carbon??14 isotope

IV Ekhato, S Bonacorsi

文献索引：Ekhato, I. Victor; Bonacorsi Jr., Samuel Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 4 p. 202 - 205

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被引用次数: 5

摘要

Abstract Irbesartan (Avapro™) is in clinical use as an antihypertensive drug. It is a nonpeptide angiotensin II receptor antagonist. A radiolabeled version of this drug, intended for use in environmental fate studies, was prepared from N, N-dimethyl [14 C] formamide. Our method of synthesis gave 18% overall yield and a radiochemical purity of 98.22%. Copyright© 2010 John Wiley & Sons, Ltd.