Organosilicon synthesis of isocyanates: IV. Synthesis of isocyanates from aliphatic and alkylaromatic amino acid esters

…, AB Lebedeva, VD Sheludyakov, VV Shatunov…

文献索引：Lebedev; Lebedeva; Sheludyakov; Shatunov; Ovcharuk Russian Journal of General Chemistry, 2007 , vol. 77, # 4 p. 581 - 585

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被引用次数: 6

摘要

Abstract Treatment of an alcoholic suspension of amino acids with trimethylchlorosilane yielded phenylglycine, valine, β-phenylalanine, and homovaline ester hydrochlorides. Their saccharin-catalyzed silylation with hexamethyldisilazane proceeds quantitatively and involves only one proton of the amino group. The best conversion of the amino acid esters to the corresponding isocyanates was achieved by phosgene treatment of their monosilyl ...