Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

MS Malamas, J Sredy, C Moxham, A Katz…

文献索引：Malamas, Michael S.; Sredy, Janet; Moxham, Christopher; Katz, Alan; Xu, Weixin; McDevitt, Robert; Adebayo, Folake O.; Sawicki, Diane R.; Seestaller, Laura; Sullivan, Donald; Taylor, Joseph R. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1293 - 1310

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被引用次数: 261

摘要

Insulin resistance in the liver and peripheral tissues, together with a pancreatic cell defect, are the common causes of Type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, at a site post binding of insulin to its receptor. Protein tyrosine phosphatases (PTPases) have been shown to be negative regulators of the insulin receptor. Inhibition of PTPases may be an effective method in the ...