Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

MS Malamas, J Sredy, C Moxham, A Katz…

Index: Malamas, Michael S.; Sredy, Janet; Moxham, Christopher; Katz, Alan; Xu, Weixin; McDevitt, Robert; Adebayo, Folake O.; Sawicki, Diane R.; Seestaller, Laura; Sullivan, Donald; Taylor, Joseph R. Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1293 - 1310

Full Text: HTML

Citation Number: 261

Abstract

Insulin resistance in the liver and peripheral tissues, together with a pancreatic cell defect, are the common causes of Type 2 diabetes. It is now appreciated that insulin resistance can result from a defect in the insulin receptor signaling system, at a site post binding of insulin to its receptor. Protein tyrosine phosphatases (PTPases) have been shown to be negative regulators of the insulin receptor. Inhibition of PTPases may be an effective method in the ...