Novel Synthesis of Difluoromethyl??Containing 1, 4??Disubstituted 1, 2, 3??Triazoles via a Click–Multicomponent Reaction and Desulfanylation Strategy

J Zhang, J Wu, L Shen, G Jin…

文献索引：Zhang, Jian; Wu, Jingjing; Shen, Li; Jin, Guanyi; Cao, Song Advanced Synthesis and Catalysis, 2011 , vol. 353, # 4 p. 580 - 584

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被引用次数: 20

摘要

Abstract Fourteen difluoromethyl-containing 1, 4-disubstituted 1, 2, 3-triazoles were synthesized via a novel copper-catalyzed click-multicomponent reaction of 2, 2-difluoro-2- phenylsulfanylethanol, sodium azide and terminal alkynes in the presence of N-(p- toluenesulfonyl) imidazole, tetrabutylammonium iodide and triethylamine, followed by reductive cleavage of the phenylsulfanyl group using tributyltin hydride and ...