Improved synthesis for the rodenticides, diphenacoum and brodifacoum

PS van Heerden, BCB Bezuidenhoudt…

文献索引：Van Heerden, Pieter S.; Bezuidenhoudt, Barend C. B.; Ferreira, Daneel Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1141 - 1146

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被引用次数: 24

摘要

An improved synthesis of the 3-[3-(p-substituted phenyl)-1, 2, 3, 4-tetrahydro-1-napththyl]-4- hydroxycoumarins, diphenacoum and brodifacoum, is described. The process is primarily based on the formation of one of the crucial bonds in the carbon backbone using organocopper methodology, and on the coupling of the 4-hydroxycoumarin moiety to the 3- biphenyl tetralin unit under strongly acidic conditions.