Dipeptide Nitrogen Mustards of Glycine and γ-Aminobutyric Acid1

SCJ Fu, H Terzian, CL Maddock…

文献索引：Fu,S.-C.J. et al. Journal of Medicinal Chemistry, 1966 , vol. 9, p. 214 - 216

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被引用次数: 2

摘要

In our investigation of dipeptide nitrogen mustards, we have synthesized the optical arid position isomers of S-[bis (2-chloroethyl) aniinobenzoyl] glutamic acid. 2 The biological activities of thew dipeptide nitrogen inustards and their benzyl2" and ethyl2 ester., were htutlied in niicrobial systems and in KB line cell culture in which moderate activities were demonstrated. In 1 hr Ehrlich ahcites mouse tunior, tlie antineoplastic. xctivitiez: ire largely ...