Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons

SB Yang, F Major, LF Tietze, M Rupnik

文献索引：Yang, Shi-Bing; Major, Felix; Tietze, Lutz F.; Rupnik, Marjan Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 315, # 1 p. 352 - 362

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被引用次数: 11

摘要

Abstract Haloperidol is known as an antagonist of dopamine D2 receptors. However, it also blocks a variety of ion channels at concentrations above the therapeutic range. Reduced haloperidol (R-haloperidol), one of the main metabolites of haloperidol, has been reported to accumulate in certain tissues, particularly in brain cortex, and it may produce the pharmacological effects associated with haloperidol treatment. In this study, we assessed ...