Development of an Automated Synthesis System for Preparation of Glucuronides Using a Solid-Phase Extraction Column Loaded with Microsomes

…, T Kitade, Y Kashima, Y Okabayashi

文献索引：Kashima, Yousuke; Kitade, Takashi; Kashima, Yuuko; Okabayashi, Yoshito Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 3 p. 354 - 358

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被引用次数: 3

摘要

An automated synthesis system using a solid-phase extraction (SPE) system and column packed with octadecylsilica (ODS), which was coated with phospholipid and loaded with dog liver microsomes, was developed for synthesis of glucuronides. Preparation of the microsome-immobilized SPE column, glucuronidation of drugs to synthesize the glucuronides and elution of the products were performed by an automated synthesis ...