Journal of the American Chemical Society

Synthesis of mokupalide

FW Sum, L Weiler

文献索引：Sum,F.W.; Weiler,L. Journal of the American Chemical Society, 1979 , vol. 101, p. 4401 - 4403

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被引用次数: 40

摘要

9 yield. Then in an application of our new alkene synthesis, 6 the 0-keto ester was converted into the corresponding enol phosphate'(NaH, CIPO (OEt) 2, Et20, O" C), which was coupled with lithium dimethylcuprate (Et20,-78--23" C) to yield the a, P-unsaturated ester 6 in 85-92% yield from 5. The ester 6 was reduced (LiAIH4, Et20, reflux, 92-98%), and the resulting alcohol was converted into the allylic bromide 7 using the two-phase procedure of van ...