Convergent synthesis and biological evaluation of syringolin A and derivatives as eukaryotic 20S proteasome inhibitors

…, B Schellenberg, M Groll, AS Bachmann…

文献索引：Clerc, Jerome; Schellenberg, Barbara; Groll, Michael; Bachmann, Andre S.; Huber, Robert; Dudler, Robert; Kaiser, Markus European Journal of Organic Chemistry, 2010 , # 21 p. 3991 - 4003

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被引用次数: 27

摘要

Abstract A convergent synthesis of SylA was developed and consists of the synthesis of a fully functionalized macrocycle, which is subsequently coupled with a urea moiety. For cyclization, ring-closing metathesis of a conformationally preorganized precursor was employed. The established synthetic route was then applied to the synthesis of SylA derivatives by using various peptidic side chains for decoration of the SylA macrocycle. ...