Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA

R Samudrala, X Zhang, RM Wadkins…

文献索引：Samudrala, Ramakrishna; Zhang, Xu; Wadkins, Randy M.; Mattern, Daniell Lewis Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 186 - 193

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被引用次数: 49

摘要

A number of N, N′-disubstituted perylenetetracarboxylic diimides have been reported to bind effectively to DNA that adopts G-quadruplex motifs. In some cases, this binding may actively drive the transition from single-strand DNA to the quadruplex form. The perylenediimides in the reported cases all have amine-containing side chains, which are thought to interact with the grooves of the quadruplex and help dictate the selectivity of ...