Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells

…, RB Hughes, DG Lloyd, DC Williams…

文献索引：Meegan; Hughes; Lloyd; Williams; Zisterer Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1072 - 1084

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被引用次数: 55

摘要

Although many series of estrogen receptor antagonists continue to be produced, the majority are direct structural analogues of existing modulators. To examine the tolerance of the estrogen receptor toward flexible ligands, a series of novel flexible estrogen receptor antagonists were prepared and their antiproliferative effects on human MCF-7 breast tumor cells investigated. Each of these compounds deviated from the traditional ...