Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells

…, RB Hughes, DG Lloyd, DC Williams…

Index: Meegan; Hughes; Lloyd; Williams; Zisterer Journal of Medicinal Chemistry, 2001 , vol. 44, # 7 p. 1072 - 1084

Full Text: HTML

Citation Number: 55

Abstract

Although many series of estrogen receptor antagonists continue to be produced, the majority are direct structural analogues of existing modulators. To examine the tolerance of the estrogen receptor toward flexible ligands, a series of novel flexible estrogen receptor antagonists were prepared and their antiproliferative effects on human MCF-7 breast tumor cells investigated. Each of these compounds deviated from the traditional ...