Carbohydrate research

An improved procedure for nucleoside synthesis using glycosyl trifluoroacetimidates as donors

J Liao, J Sun, B Yu

文献索引：Liao, Jinxi; Sun, Jiansong; Yu, Biao Carbohydrate Research, 2009 , vol. 344, # 8 p. 1034 - 1038

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被引用次数: 9

摘要

The exceptional importance of nucleic acids in life science has fueled the development of chemical synthesis methodologies of nucleosides. To date, three types of chemical synthesis strategies have been employed: (1) condensation of the sugar moiety and the base directly; (2) construction of the base moiety after introduction of a functional group at the anomeric position of the sugar moiety; (3) derivatization of naturally occurring nucleosides. 5 Compared to the last two, ...