Pyrrole chemistry. XXI. Synthetic approaches to cyanopyrroles

GH Barnett, HJ Anderson…

文献索引：Barnett, Graham H.; Anderson, Hugh J.; Loader, Charles, E. Canadian Journal of Chemistry, 1980 , vol. 58, p. 409 - 411

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被引用次数: 37

摘要

The Vilsmeier-Haack reaction with pyrrole and 1-methylpyrrole has been modified to provide a direct synthesis of the corresponding 2-nitriles. Chlorosulfonyl isocyanate may be used to prepare the same compounds, but less satisfactorily. The latter reagent does enable the synthesis of pyrrole-2, 4-dicarbonitrile in one step. This dinitrile may be reduced to pyrrole-2, 4-dicarboxaldehyde.