The structures of phyllanthostatin 1 and phyllanthoside from the Central American tree Phyllanthus acuminatus Vahl

GR Pettit, GM Cragg, D Gust, P Brown…

文献索引：Pettit, George R.; Cragg, Gordon M.; Gust, Devens; Brown, Peter; Schmidt, Jean M. Canadian Journal of Chemistry, 1982 , vol. 60, p. 939 - 941

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被引用次数: 26

摘要

A new antineoplastic glycoside, phyllanthostatin 1, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. The structures of phyllanthostatin (1 a) and phyllanthoside (1 b) were completely assigned by analyses of spectral data, principally by high resolution (400 MHz) nmr. In addition to exhibiting activity against the National Cancer Institute's P388 lymphocytic ...