The structures of phyllanthostatin 1 and phyllanthoside from the Central American tree Phyllanthus acuminatus Vahl

GR Pettit, GM Cragg, D Gust, P Brown…

Index: Pettit, George R.; Cragg, Gordon M.; Gust, Devens; Brown, Peter; Schmidt, Jean M. Canadian Journal of Chemistry, 1982 , vol. 60, p. 939 - 941

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Citation Number: 26

Abstract

A new antineoplastic glycoside, phyllanthostatin 1, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. The structures of phyllanthostatin (1 a) and phyllanthoside (1 b) were completely assigned by analyses of spectral data, principally by high resolution (400 MHz) nmr. In addition to exhibiting activity against the National Cancer Institute's P388 lymphocytic ...