Anchoring cationic amphiphiles for nucleotide delivery significance of DNA release from cationic liposomes for transfection

N Hirashima, K Minatani, Y Hattori, T Ohwada…

文献索引：Hirashima, Naohide; Minatani, Kazuhiro; Hattori, Yoshifumi; Ohwada, Tomohiko; Nakanishi, Mamoru Biological and Pharmaceutical Bulletin, 2007 , vol. 30, # 6 p. 1117 - 1122

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被引用次数: 2

摘要

We have designed and synthesized lithocholic acid-based cationic amphiphile molecules as components of cationic liposomes for gene transfection (lipofection). To study the relationship between the molecular structures of those amphiphilic molecules, particularly the extended hydrophobic appendant (anchor) at the 3-hydroxyl group, and transfection efficiency, we synthesized several lithocholic and isolithocholic acid derivatives, and ...