Anchoring cationic amphiphiles for nucleotide delivery significance of DNA release from cationic liposomes for transfection

N Hirashima, K Minatani, Y Hattori, T Ohwada…

Index: Hirashima, Naohide; Minatani, Kazuhiro; Hattori, Yoshifumi; Ohwada, Tomohiko; Nakanishi, Mamoru Biological and Pharmaceutical Bulletin, 2007 , vol. 30, # 6 p. 1117 - 1122

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Citation Number: 2

Abstract

We have designed and synthesized lithocholic acid-based cationic amphiphile molecules as components of cationic liposomes for gene transfection (lipofection). To study the relationship between the molecular structures of those amphiphilic molecules, particularly the extended hydrophobic appendant (anchor) at the 3-hydroxyl group, and transfection efficiency, we synthesized several lithocholic and isolithocholic acid derivatives, and ...