On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1, 2, 3-triazolic naphthoquinoidal …
…, JD de Souza Filho, WO Valenca, CA Camara…
文献索引：Da Silva Jr., Eufranio N.; De Melo, Isadora M.M.; Diogo, Emilay B.T.; Costa, Verenice A.; De Souza Filho, Jose D.; Valenca, Wagner O.; Camara, Celso A.; De Oliveira, Ronaldo N.; De Araujo, Alexandre S.; Emery, Flavio S.; Dos Santos, Marcelo R.; De Simone, Carlos A.; Menna-Barreto, Rubem F.S.; De Castro, Solange L. European Journal of Medicinal Chemistry, 2012 , vol. 52, p. 304 - 312
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1, 2, 3-triazolic para- naphthoquinones, five nor-β-lapachone-based 1, 2, 3-triazoles, and several other naphthoquinonoid compounds were synthesized and evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease, continuing our screening program for new trypanocidal compounds. Among all the substances, 16– ...
