Tetrahedron

One-pot production of chiral α, β-epoxy ketones from benzaldehydes and acetophenones by recyclable poly (amino acid) catalysis

W Luo, Z Yu, W Qiu, F Yang, X Liu, J Tang

文献索引：Luo, Wanrong; Yu, Zhichao; Qiu, Wenwei; Yang, Fan; Liu, Xiaofeng; Tang, Jie Tetrahedron, 2011 , vol. 67, # 29 p. 5289 - 5292

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被引用次数: 7

摘要

Abstract An efficient one-pot, two-step process was disclosed for production of chiral α, β- epoxy ketones from benzaldehydes and acetophenones catalyzed by imidazolium-modified poly (l-leucine). Two effective reaction systems with complementary high enantioselectivities (up to 98% ee) or satisfactory yields (up to 89%) have been developed. Importantly, the poly (amino acid) catalyst can be easily recovered and recycled for ten times without losing its ...