Design and synthesis of a library of tertiary amides: Evaluation as mimetics of the melanocortins' active core

…, L Borisova-Jan, A Yahorau, R Muceniece…

文献索引：Mutulis, Felikss; Kreicberga, Jana; Yahorava, Sviatlana; Mutule, Ilze; Borisova-Jan, Larisa; Yahorau, Aleh; Muceniece, Ruta; Azena, Sandra; Veiksina, Santa; Petrovska, Ramona; Wikberg, Jarl E.S. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5787 - 5810

全文：HTML全文

被引用次数: 13

摘要

Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff bases. Coupled resins were then reduced to secondary amines by sodium cyanoborohydride in 4% acetic acid/trimethyl orthoformate, ...