Design and synthesis of a library of tertiary amides: Evaluation as mimetics of the melanocortins' active core

…, L Borisova-Jan, A Yahorau, R Muceniece…

Index: Mutulis, Felikss; Kreicberga, Jana; Yahorava, Sviatlana; Mutule, Ilze; Borisova-Jan, Larisa; Yahorau, Aleh; Muceniece, Ruta; Azena, Sandra; Veiksina, Santa; Petrovska, Ramona; Wikberg, Jarl E.S. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 17 p. 5787 - 5810

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Citation Number: 13

Abstract

Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff bases. Coupled resins were then reduced to secondary amines by sodium cyanoborohydride in 4% acetic acid/trimethyl orthoformate, ...