Synthesis and antitumor activity of analogs of ifosfamide modified in the N-(2-chloroethyl) group

…, H Kusnierczyk, C Radzikowski, A Sonoda

文献索引：Misiura, Konrad; Kinas, Ryszard W.; Stec, Wojciech J.; Kusnierczyk, Halina; Radzikowski, Czeslaw; Sonoda, Akio Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 226 - 230

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被引用次数: 23

摘要

A series of 3-(2-chloroethyl)-N-(2-X-ethyl) tetrahydro-2H-1, 3, 2-oxazaphosphorin-2-amine 2- oxides with various X substituents have been prepared by cyclization of racemic ifosfamide or its enantiomers with sodium hydride and subsequent treatment of intermediary products with hydrobromic acid, diethyl hydrogen phosphate, dibenzyl hydrogen phosphate, p- toluenesulfonic acid, and acetic acid. All of these compounds were tested in vivo against L ...