A series of 3-(2-chloroethyl)-N-(2-X-ethyl) tetrahydro-2H-1, 3, 2-oxazaphosphorin-2-amine 2- oxides with various X substituents have been prepared by cyclization of racemic ifosfamide or its enantiomers with sodium hydride and subsequent treatment of intermediary products with hydrobromic acid, diethyl hydrogen phosphate, dibenzyl hydrogen phosphate, p- toluenesulfonic acid, and acetic acid. All of these compounds were tested in vivo against L ...
