Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture

Z Alvarez, K Lee, E Abel-Santos

文献索引：Alvarez, Zadkiel; Lee, Kyungae; Abel-Santos, Ernesto Antimicrobial Agents and Chemotherapy, 2010 , vol. 54, # 12 p. 5329 - 5336

全文：HTML全文

被引用次数: 8

摘要

ABSTRACT Bacillus anthracis, the etiological agent of anthrax, has a dormant stage in its life cycle known as the endospore. When conditions become favorable, spores germinate and transform into vegetative bacteria. In inhalational anthrax, the most fatal manifestation of the disease, spores enter the organism through the respiratory tract and germinate in phagosomes of alveolar macrophages. Germinated cells can then produce toxins and ...