Discovery of 6-[4-(6-nitroxyhexanoyl) piperazin-1-yl)]-9H-purine, as pharmacological post-conditioning agent

M Koufaki, T Fotopoulou, EK Iliodromitis, SI Bibli…

文献索引：Koufaki, Maria; Fotopoulou, Theano; Iliodromitis, Efstathios K.; Bibli, Sophia-Iris; Zoga, Anastasia; Kremastinos, Dimitrios Th.; Andreadou, Ioanna Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5948 - 5956

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被引用次数: 2

摘要

Novel purine analogues bearing nitrate esters were designed and synthesized in an effort to develop compounds triggering endogenous cardioprotective mechanisms such as ischemic preconditioning (IPC) or postconditioning (PostC). The majority of the compounds reduced infarct size compared to the control group in anesthetized rabbits, whereas administration of the most active analogue 16 at a dose of 3.8 μmol/kg resulted on a significant reduction of ...