前往化源商城

Synthesis and quantitative structure-activity relationships of antiallergic 2-hydroxy-N-(1H-tetrazol-5-yl) benzamides and N-(2-hydroxyphenyl)-1H-tetrazole-5- …

RE Ford, P Knowles, E Lunt, SM Marshall…

文献索引：Ford; Knowles; Lunt; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 4 p. 538 - 549

全文：HTML全文

被引用次数: 99

摘要

The synthesis and antiallergic activity of a series of 2-hydroxy-N-1H-tetrazol-5-ylbenzamides and isomeric N42-hydroxyphenyl)-lH-tetrazole-5-carboxamides is described. A relationship between structure and intravenous antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test has been established using a Hansch/Free-Wilson model and used to direct studies toward potent derivatives. The contribution of physicochemical properties ...

 相关合成线路
氯化苄结构式

100-44-7

氯化苄

~%

5-methyl-2-phenylmethoxybenzoic acid结构式

67127-92-8

5-methyl-2-phen...

methyl 2-(benzyloxy)-5-methylbenzoate结构式

424791-16-2

methyl 2-(benzy...

~%

5-methyl-2-phenylmethoxybenzoic acid结构式

67127-92-8

5-methyl-2-phen...

5'-溴-2'-羟基-3'-硝基乙酰苯结构式

70978-54-0

5'-溴-2'-羟基-3'-硝基乙酰苯

~30%

1-(3-氨基-5-溴-2-羟基苯基)乙酮结构式

70977-85-4

1-(3-氨基-5-溴-2-羟...

2'-羟基-5'-甲基-3'-硝基苯乙酮结构式

66108-30-3

2'-羟基-5'-甲基-3'-硝基苯乙酮

~48%

3-氨基-2-羟基-5-甲基苯乙酮结构式

70977-71-8

3-氨基-2-羟基-5-甲基苯乙酮

乌洛托品结构式

100-97-0

乌洛托品

2-羟基-3-甲氧基苯甲酸结构式

877-22-5

2-羟基-3-甲氧基苯甲酸

~37%

3-CARBOXY-4-HYDROXY-5-METHOXYBENZALDEHYDE结构式

3507-08-2

3-CARBOXY-4-HYD...

5-Cyano-2-hydroxy-3-nitro-acetophenon结构式

70978-59-5

5-Cyano-2-hydro...

~66%

3-Acetyl-5-amino-4-hydroxybenzonitrile结构式

70977-81-0

3-Acetyl-5-amin...

2-乙酰基对氰基苯酚结构式

35794-84-4

2-乙酰基对氰基苯酚

~%

3-Acetyl-5-amino-4-hydroxybenzonitrile结构式

70977-81-0

3-Acetyl-5-amin...

5-氨基四氮唑结构式

4418-61-5

5-氨基四氮唑

5-氟水杨酸结构式

345-16-4

5-氟水杨酸

~%

5-Fluoro-2-hydroxy-N-(2H-tetrazol-5-yl)benzamide结构式

67127-05-3

5-Fluoro-2-hydr...

N-(3-acetyl-5-fluoro-2-hydroxyphenyl)-1-benzyl-1H-tetrazole-5-carboxamide结构式

100245-24-7

N-(3-acetyl-5-f...

~64%

乙氟司特结构式

70977-46-7

乙氟司特

5-氟-2-羟基苯乙酮结构式

394-32-1

5-氟-2-羟基苯乙酮

~%

乙氟司特结构式

70977-46-7

乙氟司特

5'-FLUORO-2'-HYDROXY-3'-NITROACETOPHENONE结构式

70978-39-1

5'-FLUORO-2'-HY...

~%

乙氟司特结构式

70977-46-7

乙氟司特

3-amino-5-fluoro-2-hydroxyacetophenone结构式

70977-84-3

3-amino-5-fluor...

~%

乙氟司特结构式

70977-46-7

乙氟司特

1-(4-methoxy-benzyl)-1H-tetrazole-5-carboxylic acid 3-acetyl-5-fluoro-2-hydroxy-anilide结构式

70977-96-7

1-(4-methoxy-be...

~89%

乙氟司特结构式

70977-46-7

乙氟司特

dipotassium 1H-tetrazole-5-carboxylate结构式

70978-65-3

dipotassium 1H-...

3-amino-5-fluoro-2-hydroxyacetophenone结构式

70977-84-3

3-amino-5-fluor...

~%

乙氟司特结构式

70977-46-7

乙氟司特

1-(3-烯丙基-2-羟基苯基)乙酮结构式

58621-39-9

1-(3-烯丙基-2-羟基苯基)乙酮

~%

3-acetyl-2-hydroxybenzaldehyde结构式

55108-29-7

3-acetyl-2-hydr...

1-[2-hydroxy-3-(prop-1-enyl)phenyl]ethanone结构式

67127-96-2

1-[2-hydroxy-3-...

~%

3-acetyl-2-hydroxybenzaldehyde结构式

55108-29-7

3-acetyl-2-hydr...

1-(5-ethyl-2-hydroxyphenyl)propan-1-one结构式

63909-10-4

1-(5-ethyl-2-hy...

~25%

1-(5-ethyl-2-hydroxy-3-nitrophenyl)propan-1-one结构式

70978-47-1

1-(5-ethyl-2-hy...

2-Hydroxy-5-methyl-3-nitrotrifluoroacetophenon结构式

70978-48-2

2-Hydroxy-5-met...

~56%

Ethanone, 1-(3-amino-2-hydroxy-5-methylphenyl)-2,2,2-trifluoro- (9CI)结构式

70977-83-2

Ethanone, 1-(3-...

2,2,2-三氟-1-(2-羟基-5-甲基苯基)-乙酮结构式

70978-57-3

2,2,2-三氟-1-(2-羟...

~%

Ethanone, 1-(3-amino-2-hydroxy-5-methylphenyl)-2,2,2-trifluoro- (9CI)结构式

70977-83-2

Ethanone, 1-(3-...

N,N-dimethyl-2-nitro-1-phenol-4-sulfonamide结构式

42247-91-6

N,N-dimethyl-2-...

~66%

N-N-二甲基-3-氨基-4-羟基-1-苯磺酰胺结构式

24962-75-2

N-N-二甲基-3-氨基-4-...


首页 |  期刊大全 |  MSDS查询 |  化工产品分类 |  生物活性化合物 |  关于我们 |  免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2024 ChemSrc All Rights Reserved