Tetrahedron Letters

Development of new DMAP-related organocatalysts for use in the Michael addition reaction of β-ketoesters in water

K Ko, K Nakano, S Watanabe, Y Ichikawa, H Kotsuki

文献索引：Ko, Kyungmin; Nakano, Keiji; Watanabe, Shigeru; Ichikawa, Yoshiyasu; Kotsuki, Hiyoshizo Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4025 - 4029

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被引用次数: 17

摘要

A general and efficient protocol for the Michael addition reactions of β-ketoesters in pure water has been developed. The reactions are successfully catalyzed by newly designed DMAP-related organocatalysts such as 4-(didecylamino) pyridine, and the desired Michael adducts are obtained in good to high yields