Tetrahedron letters

A new synthesis of 1, 3-thiazines and their transformation into 1-substituted-6-alkyluracils by extrusion of carbonyl sulfide

VN Yuskovets, BA Ivin

文献索引：Yuskovets, Valera N.; Ivin, Boris A. Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5279 - 5280

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被引用次数: 19

摘要

A simple synthesis of 5-acyl-4-hydroxy-3, 6-dihydro-2H-1, 3-thiazine-2, 6-diones from malonic acid, potassium thiocyanate and acid anhydrides is described. A new, general, regioselective method for the synthesis of 1-substituted-6-alkyluracils by the reaction of these thiazines with primary alkyl and arylamines is reported.