Collection of Czechoslovak chemical communications

Synthesis and antiviral activity of acyclic nucleoside analogues of 6-methyluracil and 4-alkylamino-6-methyl-2 (1H)-pyrimidinones

S Bhat

文献索引：Bhat, Sunita Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 3 p. 683 - 690

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被引用次数: 6

摘要

Abstract Reaction of 2, 4-Dimethoxy-6-methylpyrimidine (I) with allyl bromide or benzyl bromide afforded 1-substituted 4-methoxy-6-methyl-2 (1H)-pyrimidinone intermediates III, X. Oxidation of the compound III afforded racemic cis diol VI. O-Demethylation and nucleophilic displacement of the intermediates III, VI and X gave 1-substituted 6-methyluracils IV, VII, IX and 1-substituted 4-alkylamino-6-methyl-2 (1H)-pyrimidinones V, VIII, XII in good yields. ...