Syntheses of [18 F] 5-fluoro-3-nitro-L-tyrosine

…, R Ashique, GJ Schrobilgen, K Gulenchyn

文献索引：Vasdev, Neil; Chirakal, Raman; Ashique, Rezwan; Schrobilgen, Gary J.; Gulenchyn, Karen Journal of Fluorine Chemistry, 2003 , vol. 121, # 1 p. 9 - 14

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被引用次数: 8

摘要

The detection of 3-nitro-l-tyrosine has been used as a biomarker of “reactive nitrogen species” in biological matrices and has been an ongoing challenge in analytical chemistry. In this work, fluorine-18 labelled 5-fluoro-3-nitro-l-tyrosine (FNT) was synthesized as a potential radiotracer to probe the biological fate of 3-nitro-l-tyrosine. The synthesis of [18F] FNT was carried out by reaction of [18F] 3-fluoro-l-tyrosine with NaNO3 in TFA solvent for ...