The detection of 3-nitro-l-tyrosine has been used as a biomarker of “reactive nitrogen species” in biological matrices and has been an ongoing challenge in analytical chemistry. In this work, fluorine-18 labelled 5-fluoro-3-nitro-l-tyrosine (FNT) was synthesized as a potential radiotracer to probe the biological fate of 3-nitro-l-tyrosine. The synthesis of [18F] FNT was carried out by reaction of [18F] 3-fluoro-l-tyrosine with NaNO3 in TFA solvent for ...
