Synthesis

Automated synthesis and purification of amides: Exploitation of automated solid phase extraction in organic synthesis

RM Lawrence, SA Biller, OM Fryszman, MA Poss

文献索引：Lawrence, R. Michael; Biller, Scott A.; Fryszman, Olga M.; Poss, Michael A. Synthesis, 1997 , # 5 p. 553 - 558

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被引用次数: 55

摘要

Automation of the SPE purification required identification of elution conditions that would be independent of the structure of the variable acid component. Loading of the crude product mixture onto a cation exchange SPE column followed by washing with MeOH and 0.1 N ammonia in MeOH was sufficient to completely remove the